他拉唑帕利 Talazoparib
交易须知
talazoparib产品活性：talazoparib (bmn-673) 是高效的 parp1/2 抑制剂，ki 值分别为 1.2 nm 和 0.87 nm。
研究领域：cell cycle/dna damage | epigenetics
作用靶点：parp
in vitro: talazoparib (bmn 673) demonstrates excellent potency, inhibiting parp1 and parp2 enzyme activity with ki=1.2 and 0.87 nm, respectively. talazoparib (bmn 673) exhibits selective antitumor cytotoxicity and elicits dna repair biomarkers at much lower concentrations than earlier generation parp1/2 inhibitors (such as olaparib, rucaparib, and veliparib).
in vivo: talazoparib (bmn 673; 1 mg/kg, p.o.) is orally available, displaying favorable pharmacokinetic (pk) properties and remarkable antitumor efficacy in the brca1 mutant mx-1 breast cancer xenograft model following oral administration as a single-agent or in combination with chemotherapy agents such as temozolomide and cisplatin. talazoparib (bmn 673) is readily orally bioavailable, with more than 40% absolute oral bioavailability in rats when dosed in carboxylmethyl cellulose. oral administration of talazoparib elicits remarkable antitumor activity, xenografted tumors that carry defects in dna repair due to brca mutations or pten deficiency are profoundly sensitive to oral talazoparib treatment at well-tolerated doses in mice.
相关产品：drug repurposing compound library | clinical compound library | clinical compound library plus | anti-cancer compound library | cell cycle/dna damage compound library | drug repurposing compound library plus | epigenetics compound library | bioactive compound library plus | olaparib | xav-939 | niraparib | veliparib | rucaparib phosphate | pj34 hydrochloride | pamiparib | rucaparib camsylate | g007-lk | talazoparib tosylate | azd-2461 | e7449 | nms-p118 | ag14361 | iniparib | jw 55 | a-966492 | az6102 | 3-aminobenzamide | bgp-15 | me0328 | mn-64 | nvp-tnks656 | upf 1069 | dehydrocorydaline
MedChemExpress LLC
郑先生
86-021-58955995
17321200539
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他拉唑帕利 Talazoparib
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talazoparib产品活性：talazoparib (bmn-673) 是高效的 parp1/2 抑制剂，ki 值分别为 1.2 nm 和 0.87 nm。
研究领域：cell cycle/dna damage | epigenetics
作用靶点：parp
in vitro: talazoparib (bmn 673) demonstrates excellent potency, inhibiting parp1 and parp2 enzyme activity with ki=1.2 and 0.87 nm, respectively. talazoparib (bmn 673) exhibits selective antitumor cytotoxicity and elicits dna repair biomarkers at much lower concentrations than earlier generation parp1/2 inhibitors (such as olaparib, rucaparib, and veliparib).
in vivo: talazoparib (bmn 673; 1 mg/kg, p.o.) is orally available, displaying favorable pharmacokinetic (pk) properties and remarkable antitumor efficacy in the brca1 mutant mx-1 breast cancer xenograft model following oral administration as a single-agent or in combination with chemotherapy agents such as temozolomide and cisplatin. talazoparib (bmn 673) is readily orally bioavailable, with more than 40% absolute oral bioavailability in rats when dosed in carboxylmethyl cellulose. oral administration of talazoparib elicits remarkable antitumor activity, xenografted tumors that carry defects in dna repair due to brca mutations or pten deficiency are profoundly sensitive to oral talazoparib treatment at well-tolerated doses in mice.
相关产品：drug repurposing compound library | clinical compound library | clinical compound library plus | anti-cancer compound library | cell cycle/dna damage compound library | drug repurposing compound library plus | epigenetics compound library | bioactive compound library plus | olaparib | xav-939 | niraparib | veliparib | rucaparib phosphate | pj34 hydrochloride | pamiparib | rucaparib camsylate | g007-lk | talazoparib tosylate | azd-2461 | e7449 | nms-p118 | ag14361 | iniparib | jw 55 | a-966492 | az6102 | 3-aminobenzamide | bgp-15 | me0328 | mn-64 | nvp-tnks656 | upf 1069 | dehydrocorydaline
MedChemExpress LLC
郑先生
86-021-58955995
17321200539
加盟）江山好来客门业-实木门，烤漆门，原木门，免漆门
河南高强聚合物修补砂浆价格 新乡302界面剂厂家 混合砂浆
湖北玻璃钢管道 玻璃钢夹砂管道 玻璃钢排水管道
奥美卡美式系列8803梳妆台
农家肥发酵，你需要这么做才可以！
他拉唑帕利 Talazoparib
西北异军突起 东北全线上涨 离全面上涨还远吗？
供应高效专业的口碑营销,中锦信口碑营销值得拥有
电气故障排除的方法与要领
加盟尚佰木门，怎么联系你们？
动漫新闻稿发布报价 收录好的新闻发稿平台
资讯：辽源frp玻璃钢亮瓦现货
濮阳DN800衬胶管道-可来厂考察
2019广东信宜建筑工地用洗车池选我们故障率极低
安平县防尘网厂|山西防风抑尘网|防风网
翻滚吧，滤材！当你们在鱼缸里摇摆，我笑而不语
厂家直批蝴蝶山宝贝骨汤面260克袋装含金锣酱包
全球独有X光射线安检机
李德记茯砖 安化黑茶 厂家直销 白沙溪同产地 特价热卖 茯茶
郧西县ASSAB17瑞典白钢刀厂家24*24*200